Articles

Global trends and future projections of cervical cancer burden: an integrated analysis of GBD 2021, UN population and WHO HPV vaccination data

Dongxuan Shao, Ping Wu, Huici Jiang , et al. Front Public Health 2026 Jan 26:14:1702186

Cervical cancer remains a leading cause of morbidity and mortality among women, disproportionately affecting low- and middle-income countries (LMICs). We sought to: (1) characterize temporal and geographic patterns of cervical cancer burden (1990-2021), with a focus on age-related differences; (2) identify attributable... Read More

24 Mar, 2026

Selective Elimination of Breast Surgery for Invasive Breast Cancer: A Nonrandomized Clinical Trial

Henry M Kuerer 1, Vicente Valero 2, Benjamin D Smith 3, et al. JAMA Oncol. 2025 May 1;11(5):529-534

Neoadjuvant systemic therapy (NST) has been associated with pathologic complete response (pCR) in up to 60% of breast cancers (BCs). The findings of this trial question the necessity of surgery. To report preplanned 5-year efficacy outcomes evaluating radiotherapy alone without breast surgery in patients selected with ... Read More

24 Mar, 2026

Society of Surgical Oncology Breast Disease Site Working Group Statement on Bilateral Risk-Reducing Mastectomy: Indications, Outcomes, and Risks

Puneet Singh, Doreen M Agnese, Miral Amin, et al. Ann Surg Oncol. 2025 Feb;32(2):899-911.

Bilateral risk-reducing mastectomy (BRRM) is the surgical removal of both breasts to reduce the risk of cancer. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, outcomes, and risks of BRRM to update the society's 2017 statement. We held a virtual meeting to o... Read More

24 Mar, 2026

Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study

Eva Blondeaux 1, Amir Sonnenblick 2, Elisa Agostinetto . Lancet Oncol. 2025 Jun;26(6):759-770

The BRCA BCY Collaboration is an international, hospital-based, retrospective cohort study, conducted at 109 centers in five continents, including women harboring germline BRCA1, BRCA2, or both, pathogenic or likely pathogenic variants and diagnosed with stage I–III invasive breast cancer at the age of 40 years or youn... Read More

24 Mar, 2026

Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention

Xia Wei , Lea Mansour , Samuel Oxley, et al. JAMA Oncol. 2025 Jul 24;11(9):1072-1082.

Expanding access to genetic testing and availability of validated breast cancer (BC) risk prediction models are increasingly identifying women at elevated BC risk who do not carry high-penetrance BRCA1/BRCA2/PALB2 pathogenic variants.  In the simulated cohort of 100 000 thirty-year-old women in the UK, undergoing RRM b... Read More

24 Mar, 2026

Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status

Matteo Lambertini , Eva Blondeaux , Loredana M Tomasello.et al. J Clin Oncol. 2025 May 10;43(14):1706-1719

To investigate the clinical behavior of breast cancer in young BRCA carriers according to the specific BRCA gene (BRCA1 v BRCA2) and the association of the timing of genetic testing (before v at diagnosis) with prognosis. Compared with BRCA2 carriers (n = 1,683), BRCA1 carriers (n = 3,069) had more frequently hormone r... Read More

24 Mar, 2026

Ultrasound-guided, indocyanine green-directed robot-assisted surgery for breast cancer with negative margins

Ning Liao, Nanqiu Liu, Guochun Zhang, et al. European Journal of Surgical Oncology published online January 2026

This pilot study evaluated the feasibility of a novel technique combining ultrasound-guided and indocyanine green (ICG) intra-tumoral injection with robot-assisted surgery to enable accurate local excision. A novel surgical technique combined intraoperative ultrasound and indocyanine green (ICG) injections was develop... Read More

24 Mar, 2026

Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study

Tianyi Wang, Mandy Che, Yash S. Huilgol, et al. NPJ Breast Cancer | (2024) 10:90

Breast cancer risk reduction strategies have been well-validated, but barriers remain for high-risk individuals to adopt them. We performed a study among participants with high risk of breast cancer to validate whether a virtual breast health decision tool impacted a participant’s willingness to start risk-reducing act... Read More

24 Mar, 2026

Risk-Based vs Annual Breast Cancer Screening. The WISDOM Randomized Clinical Trial

Laura J. Esserman; Allison S. Fiscalini; Arash Naeim. JAMA Published online December 12, 2025

Individual breast cancer risk can guide screening initiation, frequency, use of supplemental imaging, and preventive measures to improve breast cancer screening by shifting resources from low-risk women to high-risk women. To determine whether risk-based breast cancer screening is a feasible alternative to annual mammo... Read More

24 Mar, 2026

Global patterns and trends in breast cancer incidence and mortality across 185 countries

Joanne Kim, Andrew Harper, Valerie McCormack, et al.  Nat Med. 2025 Apr;31(4):1154-1162.

Updates of current and projected estimates of the burden are critical to monitoring the success of ongoing efforts in breast cancer control, such as the World Health Organization Global Breast Cancer Initiative, which aims to reduce breast cancer mortality by 2.5% per year. We investigated the current (2022) and future... Read More

24 Mar, 2026