Articles

Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data

Hyuna Sung, Rebecca L Siegel, Mathieu Laversanne, et al. Lancet Oncol 2025; 26: 51–63. 2025

Previous studies have shown that colorectal cancer incidence is increasing among younger adults (aged <50 years) in multiple high-income western countries in contrast with stabilizing or decreasing trends in incidence in older adults (aged ≥50 years). In the most recent 5 years (2013–17 for all countries analyse... Read More

24 Mar, 2026

Age-specific trends in colorectal, appendiceal, and anal tumor incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis

Aaron L. Meyers, James G. Dowty, Khalid Mahmood, et al. The Lancet Regional Health – Western Pacific 2025;64

Early-onset bowel cancer incidence (age <50 years) has increased worldwide. Combining all malignant tumor histologies, early-onset incidence rose 5–9% annually, yielding 4072 excess cases (1⋅5 per 100,000 person-years; 15% appendix, 28% colon, 48% rectum, 9% anus). Trends varied by site, period, and age: appendi... Read More

24 Mar, 2026

The global burden of breast cancer among women of reproductive age: a comprehensive analysis

Yuzhou Cai, Fangyi Dai, Ying Ye, et al. Sci Rep. 2025 Mar 18;15(1):9347

Breast cancer is the most prevalent malignant disease among women and affects women of reproductive age (15-49 years) across the globe. This study examines patterns and trends in the epidemiology of breast cancer in women of reproductive age using global burden of disease data (1990-2021), with the objective of in... Read More

24 Mar, 2026

Global Burden of Early-Onset Cancers Attributable to Metabolic Risk Factors from 1990 to 2021 and Projections to 2040

Wenmei 1, Kaijian Zhou 2, Liang He 3, et al. Endocrinol Metab (Seoul). 2026 Jan 5

Early-onset cancers (diagnosed in individuals under 50 years of age) are increasingly contributing to the global cancer burden. Among the known contributors, specific metabolic risk factors-namely high body mass index (BMI) and high fasting plasma glucose (FPG)-have emerged as significant determinants. This study ... Read More

24 Mar, 2026

Disparities in the incidence, mortality and disability-adjusted life years of 33 early-onset cancer groups globally, 2012-2021: a systematic analysis

Wenxin Yan, Min Liu, Wenzhan Jing et al. Exp Hematol Oncol. 2025 Mar 17;14(1):38

The global cancer burden is rising, with early-onset cancers becoming more prevalent. We aimed to investigate the burden, trend and population disparity in 33 early-onset cancers from 2012 to 2021. In 2021, there were 2.65 million new early-onset cancer cases excluding non-melanoma skin cancer (NMSC), resulti... Read More

24 Mar, 2026

Global Epidemiologic Trends of Early-Onset Cancers From 1990 to 2021 and Projection to 2040

Rupayan Kundu, Ankush Mukhopadhyay, Niladri Kal, et al .JCO Glob Oncol 12, e2500170(2026). Volume 12

Early-onset cancer (EOC), defined as cancer occurring in individuals age 15-49 years, represents a growing global health burden.  In 2021, there were approximately 23.6 million new EOC cases and 0.99 million deaths globally. The highest incidence rates were observed in breast, nonmelanoma skin, and cervical c... Read More

24 Mar, 2026