Articles

Breast Cancer Incidence Among US Women Aged 20 to 49 Years by Race, Stage, and Hormone Receptor Status

Shuai Xu, Sara Murtagh, Yunan Han,et al. JAMA Netw Open. 2024 Jan 2;7(1):e2353331

Breast cancer in young women has a less favorable prognosis compared with older women. This cross-sectional study used data from Surveillance, Epidemiology, and End Results 17 registries (2000-2019). Women aged 20 to 49 years with a primary invasive breast cancer were included. Out of 217 815 eligible women, the m... Read More

12 May, 2026

Global patterns and risk factors of breast cancer in women under 35: a population-based study

Dechuang Jiao, Jiujun Zhu, Dandan Wang, et al. Breast. 2026 Mar 23:87:104777

Accurate estimates of the global burden of young breast cancer (YBC) are lacking. In 2021, YBC accounted for substantial global disease burden, with 81,856 new cases, 687,819 prevalent cases, 18,597 deaths, and 1,178,721 DALYs. From 1990 to 2021, global ASIR (AAPC: 1.3%) and ASMR (AAPC: 0.3%) increased significant... Read More

12 May, 2026

The global burden of early-onset cancer in women, 1990-2021: findings from the GBD 2021 with focus on China

Yibei Li, Danqi Huang, Jingyi Liu, et al. J Natl Cancer Cent. 2026 Feb 11;6(2):149-158

Early-onset cancer is a significant public health threat in females, yet comprehensive data on its global burden and temporal trends remain limited. This study analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of female early-onset cancers (ages 15-49 years) from 1990 to 2021, with proje... Read More

12 May, 2026

The global epidemic of early-onset cancer: nature, nurture, or both?

S. Ogino and T. Ugai. Annals of Oncol;.35(12) 1071-1073. 2024

The incidence of early-onset cancer (EOC) diagnosed in individuals under the age of 50 has been increasing worldwide, which may be just the tip of the iceberg of larger emerging issues, including the rise of various chronic diseases across multiple generations. While this phenomenon was first recognized in colorectal c... Read More

15 Apr, 2026

Trends in the disease burden of early-onset cancers in China from 1990 to 2021: a systematic analysis of the 2021 Global Burden of Disease study

Jicun Zhu, Tiandong Li, Jiajun Chen, et al. BMC Cancer. 2025 Jul 12;25(1):1168

In recent years, the incidence of early-onset cancers among individuals under 50 years of age has been on the rise. From 1990 to 2021, the incidence rate of all early-onset cancers in China increased by 150.72 per 100,000, while the mortality and disability-adjusted life years (DALY) rates decreased by 4.30 per 100,000... Read More

15 Apr, 2026

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study

Jinming Li, Yedong Pan, Fanying Guo. Lancet Oncol.. 2025 Aug;26(8):1055-1066

The increasing incidence of early-onset colorectal cancer (age <50 years; EOCRC) shows a dramatic growing trend globally, while late-onset colorectal cancer (LOCRC) is gradually decreasing. Between Jan 1 and Dec 31, 2024, 17 133 tumor samples from patients with colorectal cancer in eight countries were analyzed. In ... Read More

24 Mar, 2026

Early-Onset Gastrointestinal Cancers: A Review

Thejus Jayakrishnan, Kimmie Ng. JAMA. 2025 Oct 21;334(15):1373-1385

Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US. Worldwide, among early-onset GI cancers rep... Read More

24 Mar, 2026

Global cancer statistics of young adults and its changes in the past decade: Incidence and mortality from GLOBOCAN 2022

Jian Li, Xiaohong Kuang. Public Health 237 (2024) 336–343

This study aimed to assess the disease burden of cancer in young adults globally and the changes between 2012 and 2022. In young adults, 47.22 % of new cases were breast, thyroid and cervical cancer, while the leading causes of cancer-related death were breast, leukemia and cervical cancer. Compared to 2012, the nu... Read More

24 Mar, 2026

The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990-2019: a secondary analysis for the global burden of disease study 2019

Jiao Su, Yuanhao Liang, Xiaofeng He, et al. Front Nutr. 2024 May 31:11:1384352

Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of early-onset CRC attributable to dietary risks remain unclear. This study aimed to estimate the burden of early-onset CRC attributable to dietary risk factors globally, regionally, and nation... Read More

24 Mar, 2026

Increase of early-onset colorectal cancer: a cohort effect

Laura Downham, Mathieu Laversanne , Sandra Perdomo, et al JNCI: Journal of the National Cancer Institute, 2025, 00(00), 1–6

Increasing incidence rates of early-onset colorectal cancer (ie, <50years of age) have been reported across multiple countries. We investigated long-term cancer incidence data from 1995 or earlier from Australia, Canada, England, and the United States separately by sex. All countries showed increasing early-onse... Read More

24 Mar, 2026