Articles

Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

Michael Bretthauer, Magnus Løberg, Paulina Wieszczy, et al. N Engl J Med. 2022;387:1547-1556

We performed a pragmatic, randomized trial involving presumptively healthy men and women 55 to 64 years of age drawn from population registries in Poland, Norway, Sweden, and the Netherlands between 2009 and 2014. The participants were randomly assigned in a 1:2 ratio either to receive an invitation to undergo a single... Read More

15 Apr, 2026

Screening and eradication of Helicobacter pylori for gastric cancer prevention: Taipei Global Consensus II

Jyh-Ming Liou , Peter Malfertheiner , Tzu-Chan Hong , et al. Gut. 2025 Oct 8;74(11):1767-1791

Eradication of H pylori, the primary cause of gastric cancer, reduces the risk of gastric cancer across all age groups, with the greatest risk reduction before the onset of premalignant conditions. H pylori eradication also promotes ulcer healing, prevents ulcer recurrence and reduces the risk of NSAID/aspirin related ... Read More

15 Apr, 2026

Tyrer-Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma

Divya Rao , Chloe Wernecke, Lisa Baron, et al. Breast J. 2026 Jan 19:2026:8670441

The Tyrer-Cuzick (TC) or IBIS risk calculator is a widely used tool to estimate the probability of developing breast cancer. The TC is commonly used to guide patients toward further diagnostic imaging, genetic testing, chemoprevention, or risk-reducing surgery. A population of 964 patients with TC was evaluated for 12 ... Read More

15 Apr, 2026

Breast cancer genetics and risk assessment: an overview for the clinician

L Larkin. Climacteric. 2023 Jun;26(3):229-234

Breast cancer is the most common cancer in women globally with enormous associated morbidity, mortality and economic impact. Prevention of breast cancer is a global public health imperative. To date, most of our global efforts have been directed at expanding population breast cancer screening programs for early cancer ... Read More

15 Apr, 2026

Breast cancer statistics 2024

Angela N Giaquinto , Hyuna Sung , Lisa A Newman , et al CA Cancer J Clin. 2024 Nov-Dec;74(6):477-495

Breast cancer incidence continued an upward trend, rising by 1% annually during 2012-2021, largely confined to localized-stage and hormone receptor-positive disease. A steeper increase in women younger than 50 years (1.4% annually) versus 50 years and older (0.7%) overall was only significant among White women. Asian A... Read More

15 Apr, 2026

Global burden, trends, and attributable risk factors of women's cancers with projection to 2050: Results from the GLOBOCAN 2022 and global burden of disease study 2021

Tingting Wei , Yunhai Li , Ze Zhang , et al. Eur J Surg Oncol. 2026 Mar 7;52(5):111742

Women's cancers pose a significant global health burden, with pronounced geographical and age-related disparities. Targeting modifiable risk factors and enhancing healthcare access, especially in low-SDI regions, is essential to reducing the worldwide burden of women's cancers. In 2022, there were 3.7 million new cases... Read More

15 Apr, 2026

The global epidemic of early-onset cancer: nature, nurture, or both?

S. Ogino and T. Ugai. Annals of Oncol;.35(12) 1071-1073. 2024

The incidence of early-onset cancer (EOC) diagnosed in individuals under the age of 50 has been increasing worldwide, which may be just the tip of the iceberg of larger emerging issues, including the rise of various chronic diseases across multiple generations. While this phenomenon was first recognized in colorectal c... Read More

15 Apr, 2026

Trends in the disease burden of early-onset cancers in China from 1990 to 2021: a systematic analysis of the 2021 Global Burden of Disease study

Jicun Zhu, Tiandong Li, Jiajun Chen, et al. BMC Cancer. 2025 Jul 12;25(1):1168

In recent years, the incidence of early-onset cancers among individuals under 50 years of age has been on the rise. From 1990 to 2021, the incidence rate of all early-onset cancers in China increased by 150.72 per 100,000, while the mortality and disability-adjusted life years (DALY) rates decreased by 4.30 per 100,000... Read More

15 Apr, 2026

The Economic Burden of Lung Cancer in Low- And Lower-Middle-Income Countries: A Systematic Review

Elyesa Ünal, Elena Goodchild, Volker Winkler, et al. Arch Public Health. 2025 Oct 13;83(1):243

Lung Cancer is one of the four most frequent malignant neoplasms in the world, and first in mortality. In 2020, lung cancer resulted in roughly 1.8 million deaths globally. Lung cancer is a major public health problem in low and lower-middle income countries, where high rates of tobacco smoking, environmental pollution... Read More

15 Apr, 2026

A Game-Changing 20 Years: Progress and Future Directions in Lung Cancer Screening

Stephen Lam,David R. Baldwin, Anand Devaraj, et al. Journal of Thoracic Oncology Vol. 21 No. 2: 235–252

In the past two decades, lung cancer screening (LCS) with low-dose computed tomography (LDCT) has emerged as one of the most effective strategies for reducing lung cancer mortality. Landmark trials, including NLST and NELSON, demonstrated mortality reductions exceeding 20%, establishing LDCT as the standard of care for... Read More

15 Apr, 2026