Articles

Increase of early-onset colorectal cancer: a cohort effect

Laura Downham, Mathieu Laversanne , Sandra Perdomo, et al JNCI: Journal of the National Cancer Institute, 2025, 00(00), 1–6

Increasing incidence rates of early-onset colorectal cancer (ie, <50years of age) have been reported across multiple countries. We investigated long-term cancer incidence data from 1995 or earlier from Australia, Canada, England, and the United States separately by sex. All countries showed increasing early-onse... Read More

24 Mar, 2026

Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data

Hyuna Sung, Rebecca L Siegel, Mathieu Laversanne, et al. Lancet Oncol 2025; 26: 51–63. 2025

Previous studies have shown that colorectal cancer incidence is increasing among younger adults (aged <50 years) in multiple high-income western countries in contrast with stabilizing or decreasing trends in incidence in older adults (aged ≥50 years). In the most recent 5 years (2013–17 for all countries analyse... Read More

24 Mar, 2026

Age-specific trends in colorectal, appendiceal, and anal tumor incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis

Aaron L. Meyers, James G. Dowty, Khalid Mahmood, et al. The Lancet Regional Health – Western Pacific 2025;64

Early-onset bowel cancer incidence (age <50 years) has increased worldwide. Combining all malignant tumor histologies, early-onset incidence rose 5–9% annually, yielding 4072 excess cases (1⋅5 per 100,000 person-years; 15% appendix, 28% colon, 48% rectum, 9% anus). Trends varied by site, period, and age: appendi... Read More

24 Mar, 2026

The global burden of breast cancer among women of reproductive age: a comprehensive analysis

Yuzhou Cai, Fangyi Dai, Ying Ye, et al. Sci Rep. 2025 Mar 18;15(1):9347

Breast cancer is the most prevalent malignant disease among women and affects women of reproductive age (15-49 years) across the globe. This study examines patterns and trends in the epidemiology of breast cancer in women of reproductive age using global burden of disease data (1990-2021), with the objective of in... Read More

24 Mar, 2026

Global Burden of Early-Onset Cancers Attributable to Metabolic Risk Factors from 1990 to 2021 and Projections to 2040

Wenmei 1, Kaijian Zhou 2, Liang He 3, et al. Endocrinol Metab (Seoul). 2026 Jan 5

Early-onset cancers (diagnosed in individuals under 50 years of age) are increasingly contributing to the global cancer burden. Among the known contributors, specific metabolic risk factors-namely high body mass index (BMI) and high fasting plasma glucose (FPG)-have emerged as significant determinants. This study ... Read More

24 Mar, 2026

Disparities in the incidence, mortality and disability-adjusted life years of 33 early-onset cancer groups globally, 2012-2021: a systematic analysis

Wenxin Yan, Min Liu, Wenzhan Jing et al. Exp Hematol Oncol. 2025 Mar 17;14(1):38

The global cancer burden is rising, with early-onset cancers becoming more prevalent. We aimed to investigate the burden, trend and population disparity in 33 early-onset cancers from 2012 to 2021. In 2021, there were 2.65 million new early-onset cancer cases excluding non-melanoma skin cancer (NMSC), resulti... Read More

24 Mar, 2026

Global Epidemiologic Trends of Early-Onset Cancers From 1990 to 2021 and Projection to 2040

Rupayan Kundu, Ankush Mukhopadhyay, Niladri Kal, et al .JCO Glob Oncol 12, e2500170(2026). Volume 12

Early-onset cancer (EOC), defined as cancer occurring in individuals age 15-49 years, represents a growing global health burden.  In 2021, there were approximately 23.6 million new EOC cases and 0.99 million deaths globally. The highest incidence rates were observed in breast, nonmelanoma skin, and cervical c... Read More

24 Mar, 2026

PreveCan, an app for cancer prevention based on the 2018 WCRF/AICR guidelines: development and usability

Emma Ruiz-Moreno, Javier García-Péreza,Virginia Lope. Gaceta Sanitaria 40 (2026) 102565

PreveCan is a useful tool to inform Spanish-speaking users on lifestyle changes to reduce cancer risk by assessing adherence to WCRF/AICR cancer prevention guidelines. The app was developed using a user-centred design approach involving epidemiology, medical, nutrition and software design experts and public. PreveCan e... Read More

24 Mar, 2026

Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study

Eva Blondeaux1, Amir Sonnenblick, Elisa Agostinetto et al. Lancet Oncol. 2025 26(6):759-770

We investigated the association between risk-reducing mastectomy (RRM) or risk-reducing salpingo-oophorectomy (RRSO), or both procedures, with survival outcomes in a large global cohort of young BRCA carriers with previous breast cancer.  Between Jan 1, 2000, and Dec 31, 2020, 5290 patients were included, of whom ... Read More

24 Mar, 2026

Scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021

GBD 2021 Tobacco Forecasting Collaborators Lancet Public Health. 2024 Oct;9(10):e729-e744

Smoking is the leading behavioral risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been p... Read More

24 Mar, 2026