Isabelle A. Lucas Beckett, Kate R. Emery, Josiah T. Wagner. npj Genomic Medicine | (2025) 10:50
Genomic medicine is now at a point where increased sequencing speed, cost reduction, and scalable cloud platforms can enable population-scale clinical sequencing. As 88% of US hospitals are community hospitals, integrating genomics into community healthcare represents a significant opportunity for greater genomic access. The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients’ lifetimes. We included multi-lingual outreach to underrepresented groups, a novel electronic informed consent and education platform, and whole genome sequencing with clinical return of results and electronic health record integration for 78 hereditary disease genes and four pharmacogenes. Whole genome sequences were banked for research and variant reanalysis. The program provided genetic counseling, pharmacist support, and guideline-based clinical recommendations for patients and their providers. Over 30,800 potential participants were initially contacted, with 2716 consenting and 2017 having results returned (47.5% racial and ethnic minority individuals). Overall, 432 (21.4%) had test results with one or more management recommendations related to hereditary disease(s) and/or pharmacogenomics. We propose Geno4ME as a framework to integrate population health genomics into routine healthcare.
24 Mar, 2026